The Reds are without Alberto Moreno after the Spaniard picked up an injury in training yesterday. That means James Milner – who missed last week’s match due to illness – comes into the side, with Nathaniel Clyne switching to left-back and Milner at right-back.
Kick off at Old Trafford is 8.05pm (GMT).
Liverpool: Mignolet, Milner, Lovren, Sakho, Clyne, Can, Henderson, Lallana, Coutinho, Firmino, Sturridge.
Subs: Ward, Toure, Smith, Allen, Ibe, Origi, Benteke.
Man United: De Gea; Varela, Smalling, Blind, Rojo; Carrick, Fellaini; Lingard, Mata, Martial; Rashford.
Subs: Romero, Darmian, Valencia, Williams, Schneiderlin, Schweinsteiger, Memphis.