The Reds do battle with their north-west rivals this weekend, in what will be the 51st meeting between the pair since the Premier League‘s inception in 1992.
Liverpool have won eight of the 25 games played at home, United have prevailed 12 times and the other five matches have ended in draws.
In those meetings, we have seen some special goals scored by Reds players, and the above video celebrates the top 10 Anfield strikes against United in the Premier League.
Starting the countdown is Robbie Fowler’s sublimely-taken effort back in March 2001 – his last ever goal against United for Liverpool.
Fernando Torres is next up, with the Spaniard displaying great strength to hold off Rio Ferdinand before firing home in front of the Kop in 2009/10.
Fowler then makes his second appearance, finishing off a slick move that saw Steve McManaman play a pivotal role, and Daniel Sturridge‘s close-range header in 2013/17 is at number seven.
Michael Owen may have irked many when he moved to Old Trafford in 2009, but his inch-perfect finish against them eight years earlier came at a time when he was the star man at Anfield.
A superb Ian Rush strike start the top-five, with the legendary strike half-volleying a shot into the Anfield Road net.
David N’Gog is at four, after his breakaway goal sealed victory in the same game as Torres’ aforementioned strike, and Fowler’s third goal in the countdown is a free-kick that wrong-foots Peter Schmeichel.
Just missing out on top spot is John Arne Riise’s stunning free-kick from November 2001, and as is so often the case with anything to do with Liverpool, Steven Gerrard tops the pile.
The former captain’s thunderous strike eight months before Riise’s will forever be seen as one of his greatest ever Reds goals, and it really announced him as a special talent.
Which would be your number one?