Klopp rotated his selection for Tuesday night’s Champions League last-16 second leg at home to Porto, and witnessed a drab but comfortable 0-0 draw at Anfield.
Progress to the quarter-finals of Europe’s top tier was already a foregone conclusion after the first leg, but less clear is the race for a top-four finish in the league.
United begin the weekend two points ahead of Liverpool, with fourth-placed Tottenham two points behind, underlining the importance of a win at Old Trafford.
Therefore, it is no surprise to see Klopp revert to his first-choice starting lineup in Manchester.
Loris Karius is retained in goal.
Karius kept another clean sheet against Porto despite operating behind a much-changed back line, but a regular setup of Trent Alexander-Arnold, Dejan Lovren, Virgil van Dijk and Andrew Robertson is restored at United.
Liverpool: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Can, Oxlade-Chamberlain, Milner; Salah, Mane, Firmino
Substitutes: Mignolet, Matip, Gomez, Wijnaldum, Henderson, Lallana, Solanke
Man United: De Gea; Valencia, Bailly, Smalling, Young; Matic, McTominay; Sanchez, Mata, Rashford; Lukaku
Substitutes: Romero, Lindelof, Darmian, Shaw, Carrick, Fellaini, Lingard