The Reds travel to Wembley looking to keep up their 100 percent record in 2018/19, although Saturday will be comfortably their biggest test yet.
Last season’s 4-1 defeat to Spurs was one of the lowest moments of Jurgen Klopp‘s tenure, and the German will be hellbent on erasing that memory.
The meeting of two of the country’s best sides is clearly the standout fixture over the next few days, but what about the rest of the action?
Here’s a look at the other nine matches taking place.
Bournemouth vs. Leicester – Saturday, 3pm
Their home meeting with Leicester City on Saturday should be an aesthetically pleasing contest—one that should have goals and attacking football aplenty.
The Foxes gave Liverpool a tough time of things last time around and they will fancy their chances of getting at least a point.
Prediction: Bournemouth 2-2 Leicester
Chelsea vs. Cardiff – Saturday, 3pm
Cardiff City are doing their best in the top flight, showing plenty of heart, but they look the weakest team in the division.
Life doesn’t get any easier for Neil Warnock’s side this weekend, as they head to Stamford Bridge to take on a Chelsea team who have so far taken maximum points.
Anything can happen in the Premier League, but it is extremely difficult to see anything other than the most comfortable of home wins.
Prediction: Chelsea 2-0 Cardiff
Huddersfield vs. Crystal Palace – Saturday, 3pm
A contender for last game on Match of the Day on Saturday night, Huddersfield Town’s visit of Crystal Palace doesn’t look like one for the footballing purists.
They have amassed just one win between them this season—Palace’s opening-day victory at Fulham—and it feels a more important game for Huddersfield, who look like relegation fodder.
In one corner there’s Klopp’s best mate David Wagner, and in the other, Liverpool’s worst-ever manager Roy Hodgson—you know who to support.
Prediction: Huddersfield 1-1 Crystal Palace
Man City vs. Fulham – Saturday, 3pm
City are such a dominant force at the Etihad that it is almost impossible to see them slipping up against anyone other than a top-four rival.
Depending on what has happened earlier in the day at Wembley, and also at Stamford Bridge at the same time, Pep Guardiola’s champions could be top with a win.
Prediction: Man City 4-1 Fulham
Newcastle vs. Arsenal – Saturday, 3pm
The Gunners still don’t look wholly convincing, but they will feel they can edge out a Newcastle United team desperately searching for points.
Rafa Benitez has a huge job on his hands this season, as off-field matters continue to cause friction.
It could be another disgruntled St James’ Park crowd after the final whistle.
Prediction: Newcastle 1-2 Arsenal
Watford vs. Man United – Saturday, 5.30pm – BT Sport
Right, who else tipped Watford relegation in the weeks leading up to the season?
Come on, it wasn’t just all of us at This is Anfield!
The Hornets have won every match to date, including an impressive triumph over Spurs last time out, and next up are Man United at Vicarage Road.
A routine win at Burnley has given Jose Mourinho some breathing space, and despite Watford looking surprisingly good in recent weeks, these are the fixtures United quietly prevail in and tally up the points.
Wolves vs. Burnley – Sunday, 1.30pm – Sky Sports
If momentum is building at Molineux, that is something Burnley can only dream of at the minute, following a tricky last month.
The Europa League has wreaked havoc with their league form—they sit 19th with just one point to their name—and they will be underdogs on Sunday afternoon.
Being out of Europe should aid the Clarets, however, so could this be the beginning of an upturn in fortunes?
Prediction: Wolves 2-1 Burnley
Everton vs. West Ham – Sunday, 4pm – Sky Sports
Giving Everton any kind of praise is never nice, but they arguably merit being higher than their current seventh place suggests.
Red cards have proved costly, turning likely wins into draws, and Marco Silva has made a solid start after replacing Sam Allardyce.
Southampton vs. Brighton – Monday, 8pm – Sky Sports
The waction ends with a south-coast battle at St Mary’s, although the pre and post-match brilliance of Jamie Carragher and Gary Neville in the Monday Night Football studio could be more worth your while.
Both Southampton and Brighton should be good enough to avoid the drop, but neither will exactly set the world alight.
It is a tough game to predict, with a share of the spoils feeling most likely.
Prediction: Southampton 1-1 Brighton