Following a disappointing 3-0 defeat at the hands of Watford last time out, the Reds are back in action and looking for an immediate response.
Liverpool find themselves in the last 16 thanks to the efforts of the club’s youngest-ever assembled side securing a 1-0 win over Shrewsbury, and Klopp has looked to reward a number of youngsters with a place in the matchday squad.
They are mixed with a host of senior figures as the boss contends with three games in the space of eight days, starting with the clash at Stamford Bridge.
Adrian takes his place between the sticks for the first time since the trip to Shrewsbury in January, in what is his 16th appearance this season.
Chelsea: Kepa; Azpilicueta, Rudiger, Zouma, Alonso; Gilmour, Kovacic, Barkley; Pedro, Willian, Giroud
Substitutes: Caballero, Tomori, James, Jorginho, Mount, Anjorin, Batshuayi
Substitutes: Lonergan, Matip, Milner, Chirivella, Oxlade-Chamberlain, Salah, Firmino