Like their substitution in the second-half against the Swans last weekend, Joe Allen replaces Raheem Sterling, who is named on the bench.
Glen Johnson keeps his place at left-back after coming back into the squad after injury last week, whilst Victor Moses and Iago Aspas are named amongst the substitutes.
Mamadou Sakho, Lucas Leiva and Jose Enrique all remain injured for Rodgers’ side.
Liverpool: Mignolet, Johnson, Flanagan, Agger, Skrtel, Gerrard, Allen, Henderson, Coutinho, Sturridge, Suarez
Substitutes: Jones, Toure, Cissokho, Moses, Aspas, Sterling, Teixeira.
Southampton: Boruc, Chambers, Fonte, Lovren, Shaw, Cork, Schneiderlin, Davis, Lallana, Rodriguez, Lambert.
Substitutes: Gazzaniga, Clyne, Yoshida, Ramírez, Wanyama, Ward-Prowse, Gallagher.
Liverpool haven’t won at St Mary’s in 11 years, when Emile Heskey ended a 19-match goal drought to score the only goal of the game for Gerard Houllier’s Reds.
Southampton v Liverpool gets underway at 5.30pm and is live on Sky Sports 1. Highlights are on BBC One’s Match of the Day from 10.30pm on Saturday night.