Both Lucas and Borini made positive impacts when they came on during the second-half of Liverpool’s 2-1 victory over Ludogorets in the Champions League in mid-week and are rewarded today.
Skrtel returns in place of Mamadou Sakho, with Dejan Lovren expected to revert to left centre-back.
Former Liverpool winger Stewart Downing lines up for the Hammers.
Liverpool won this fixture last season, beating West Ham 2-1 thanks to two Steven Gerrard penalties back in April.
Liverpool: Mignolet, Manquillo, Moreno, Lovren, Skrtel, Gerrard, Henderson, Lucas, Sterling, Borini, Balotelli.
Substitutes: Jones, Toure, Enrique, Sakho, Markovic, Lallana, Lambert.
Substitutes: Jaaskelainen, Zarate, Vaz Te, Jenkinson, Collins, Amalfitano, Cole.
West Ham v Liverpool gets underway at 5.30pm and is live on Sky Sports 1 in the UK.