Here, Press Association Sport picks over the weekend’s potential issues.
North London Bragging Rights
The north London derby is always an intense occasion, but the race for a Champions League berth adds extra spice to the Wembley encounter.
Spurs are unbeaten in eight league matches and sit fifth, boasting a four-point cushion over the Gunners.
Arsene Wenger’s reinforced side are looking to avoid a third straight away defeat in the Premier League and do have a knack of emerging victorious at Wembley.
Former England Managers Face Off
Under-fire Sam Allardyce’s side have dramatically tailed off, winning just one of their last eight games, while Roy Hodgson has inspired the Eagles to resurgence since being parachuted in.
Palace have lost only two of their previous 15 top-flight games and Hodgson will be hoping to compound matters for his England successor.
Mahrez and Man City
In years to come, Riyad Mahrez will be fondly remembered at Leicester for his heroics in their remarkable title win.
However, the Algerian is doing his best to sully his legacy, by sulking ever since Manchester City’s deadline-day move failed to come to fruition.
Only on Friday did Mahrez think of returning to train with his employers, who, as it happens, face Pep Guardiola’s men this weekend.
Claude Puel had already said the attacking midfielder will not feature, but his shadow is sure to loom large.
Van Dijk’s St Mary’s Return
The Dutch defender threw his toys out of the pram when Saints stood firm amid the advances of Jurgen Klopp’s side in the summer and was nowhere near his best when he skulked back into the squad.
Conte on Thin Ice
Antonio Conte may have won the title in his first season at Stamford Bridge but he is treading on thin ice right now, with owner Roman Abramovich surely getting an itchy trigger finger.
Favourite to be the next manager to lose his job, nothing but victory against rock-bottom West Brom will do on Monday.