Jurgen Klopp‘s men head into the top-of-the-table clash without momentum on their side, having picked up just two points from the last available nine.
However, as the old cliche goes, form goes out of the window in games such as these and the Reds will hope that this fixture gets the wheels in motion once more.
Currently, United sit three points ahead of Liverpool and a victory for the home side would move Klopp’s men above them on goal difference.
It is set to be an interesting battle between the two teams, especially after a week of the narrative circling around penalties and referees, but the three points are the goal.
So can the Reds get the job done today and make it 68 league games unbeaten at Anfield?
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live coverage and all the reaction and analysis.
The match gets underway at 4.30pm (GMT) – or 11.30am in New York, 8.30am in Los Angeles, 3.30am (Monday) in Sydney, 8.30pm in Dubai and 7.30pm in Nairobi.
Reds fans can get take advantage of adding all 8 Sky Sports channels for £25 per month or save over 15% with two channels for the price of one here.
Check our Rest of the World TV guide below for a list of TV broadcasters showing the match live.
Rest of the World
Supporters can find the Reds’ all-important Anfield clash on the following channels worldwide:
SuperSport 2 Digitalb, beIN Sports HD 2, beIN Sports HD 1, beIN SPORTS CONNECT, RMC Sport 1, DStv Now, SuperSport Premier League ROA, SuperSport Maximo, Flow Sports App, Flowsports.co, ESPN2 Sur, ESPN Play Sur, RUSH, Optus Sport, Sky Go, Sky Sport UHD, Sky Sport 1/HD, Idman TV, Star Sports Select HD1, Belarus 5, VOOsport World 1, Play Sports 1, Canal+ Sport 3 Afrique, Watch ESPN Brasil, ESPN Brasil, GUIGO, Astro Go, Play Diema Xtra, Diema Sport 2, DAZN, QQ Sports Live, PPTV Sport China, ESPN2 Colombia, Sky HD, DIGI GO, Premier Sport, Viaplay Denmark, Xee, V Sport Ultra HD, TV3 Sport, V Sport Jalkapallo, V Sport Premium, Viaplay Finland, Canal+ Sport, RMC Sport en direct, Free, Sky Ticket, Cosmote Sport 2 HD, 620 Now Premier League TV, 621 Now Premier League 1, Now Player, Digi Sport 1, SíminnSport, Hotstar VIP, Star Sports Select 1, NET., Mola TV, Mola TV App, mola.tv, SKY GO Extra, Sport 2, Sky Sport Football, SKY Go Italia, Sky Sport Uno, NOW TV, Setanta Sports Kazakhstan, TV3 Sport, Astro Go, Astro SuperSport 3, GO TV Anywhere, TSN2 Malta, Blue To Go Video Everywhere, Skynet Myanmar, Ziggo Sport 14, Ziggo Sport Select, Spark Sport, SuperSport Premier League Nigeria, TV2 Sport Premium, TV2 Sumo, Premier FOOTBALL, Canal+ Sport Online, nc+ GO, Sport TV2, Sport TV LIVE, Eurosport Romania, Eurosport Player Romania, Okko Sport, Viaplay Sweden, True Premier Football HD 2, True Premier Football HD 1, S Sport+, S Sport, Setanta Sports Ukraine, Peacock, SiriusXM FC
You can follow all the action tonight and throughout 2020/21 with us by downloading the This is Anfield app for iPhone and Android for free.