Kenny Dalglish has surprisingly opted to play both Martin Kelly and Glen Johnson, with Jose Enrique on the bench. Johnson will likely play left back.
Charlie Adam has been dropped for Gerrard, while Maxi Rodriguez isn’t in the squad.
For City, they are without key man David Silva. Mario Balotelli has been passed fit and starts. Adam Johnson also plays.
Liverpool: Reina, Kelly, Skrtel, Agger, Johnson, Spearing, Gerrard, Henderson, Downing, Bellamy, Carroll.
Subs: Doni, Enrique, Coates, Kuyt, Carragher, Adam, Shelvey.
Man City: Hart, Richards, Savic, Lescott, Clichy, Barry, de Jong, A. Johnson, Milner, Balotelli, Aguero.
Subs: Pantilimon, Zabaleta, Kolarov, Onuoha, Hargreaves, Nasri, Dzeko.
Kick off is 7:45pm at Eastlands, live on BBC One (UK).