Robin van Persie (groin), Emmanuel Adebayor (hamstring), Manuel Almunia (ankle), Gael Clichy (back), William Gallas (knee) and Johan Djourou (knee) are all sidelined.
With Arsenal still going strong in the Champions League, preparing to face Manchester United in the competition’s semi-final, manager Arsene Wenger may be tempted not to risk his remaining big players.
The Gunners do however welcome back Bacary Sagna, who has had a virus, and Eduardo. Lukasz Fabianski will again fill in for Almunia in their goal.
Kick-off at Anfield tonight is 8pm.