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The Belgian international goalkeeper gets the nod to start in goal for Brendan Rodgers’ men, whilst Toure begins the game in central defence alongside Daniel Agger.
Rodgers’ other signings of the summer Luis Alberto and Iago Aspas are on the bench, and should feature later in the game.
Liverpool: Mignolet, Spearing, Agger, Toure, Flanagan, Henderson, Allen, Assaidi, Ibe, Coutinho, Borini.
Subs: Ward, Johnson, Skrtel, Wisdom, Robinson, Lucas, Alberto, Pacheco, Aspas, Sterling, Downing, Kelly.
Kick-off at Deepdale is 3pm. Follow our updates of the game on our Twitter feed @thisisanfield throughout the afternoon.