The Spanish left-back lines up alongside Martin Skrtel and Dejan Lovren, with Glen Johnson moving to right-back.
New signing Lazar Markovic is among the subs and could make his debut for the club.
Liverpool: Mignolet, Johnson, Lovren, Skrtel, Moreno, Gerrard, Henderson, Allen, Coutinho, Sterling, Sturridge.
Substitutes: Jones, Manquillo, Sakho, Toure, Can, Markovic, Lambert
Man City: Hart, Zabaleta, Kompany, Demichelis, Clichy, Fernando, Yaya, Nasri, Silva, Jovetic, Dzeko.
Substitutes: Caballero, Sagna, Kolarov, Fernandinho, Milner, Navas, Aguero.
Man City v Liverpool gets underway at 8pm tonight and is live on Sky Sports 1 in the UK. Follow us on Twitter @thisisanfield for live updates or join fans in our Liverpool FC Forums for in-match discussion.