Origi has returned to Klopp’s starting lineup, after a masterclass away in Dortmund last week, with the Liverpool manager making six changes to the side that won 4-1 at home to Stoke City on Sunday afternoon.
Simon Mignolet keeps his place in goal, while Alberto Moreno and Nathaniel Clyne continue at left- and right-back respectively, but Dejan Lovren and Mamadou Sakho return to take up their roles at the centre of defence.
With Origi’s goal in last week’s 1-1 draw at the Westfalenstadion handing Liverpool a slim advantage heading into this clash, Klopp will be keen to add another early on as he pushes for the Europa League semi-finals with a triumph over his former club.
Liverpool: Mignolet; Clyne, Lovren, Sakho, Moreno; Can, Milner; Lallana, Firmino, Coutinho; Origi
Substitutes: Ward, Skrtel, Smith, Lucas, Allen, Ojo, Sturridge
Borussia Dortmund: Weidenfeller; Piszczek, Sokratis, Hummels, Schmelzer; Weigl, Castro; Mkhitaryan, Kagawa, Reus; Aubameyang
Substitutes: Burki, Ginter, Bender, Sahin, Gundogan, Pulisic, Ramos