Earlier in the season, Jurgen Klopp‘s side bulldozed their historic rivals on their way to a 3-1 victory, but United are now under new management, with positivity restored in Manchester following the appointment of Ole Gunnar Solskjaer.
No side in the English top flight were in better form than United heading into the weekend, with City second in the form table and Liverpool sixth, below Burnley.
But with the stakes so high, Klopp will demand a top-level display befitting of title winners, so this afternoon promises an enthralling clash.
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live coverage and all the reaction and analysis.
The match gets underway at 2.05pm (GMT)—or 9.05am in New York, 6.05am in Los Angeles, 1.05am (Monday) in Sydney, 6.05pm in Dubai and 5.05pm in Nairobi.
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Rest of the World
Supporters can find the Reds’ huge clash at Old Trafford on the following channels worldwide:
SuperSport 2 Digitalb, beIN Sports HD 2, beIN SPORTS CONNECT, beIN Sports HD 11, RMC Sport 1, SuperSport 3 Africa, Flow Sports 1, Flow Sports App, DIRECTV Sports Argentina, DIRECTV Play Deportes, DIRECTV Sports Caribbean, Optus Sport, DAZN, Idman TV, Play Sports 2, VOOsport World 1, SportKlub 2 Serbia, Watch ESPN Brasil, ESPN Brasil, Astro Go, beIN Sports 1 Thailand, Diema Sport 2, TSN5, TSN GO, TSN4, DIRECTV Sports Chile, QQ Sports Live, Ssports Live, BesTV, PPTV Sport China, DIRECTV Sports Colombia, Sky HD, Sportklub 2 Croatia, Cytavision Sports HD, Cytavision Sports 6, Digi Sport 4, DIGI GO, Viaplay Denmark, Viasat Ultra HD, Eurosport Player Denmark, TV3+ HD, DIRECTV Sports Ecuador, TVPlay Sports, Viaplay Finland, Viasat Sports Premium, Viasat Football HD, RMC Sport en direct, 620 Now Premier League TV, 621 Now Premier League 1, Now Player, Now E, Spiler1, Stod 2 Sport, Hotstar, beIN Sports Connect Indonesia, beIN Sports 1 Indonesia, MNC TV, SKY Go Italia, Sky Sport Uno, Sky Sport Football, J Sports 2, SportsNavi Live, Setanta Sports Kazakhstan, SPOTV ON 2, SPOTV2, Astro SuperSport 3, GO TV Anywhere, TSN2 Malta, Blue To Go Video Everywhere, SPS HD, Ziggo Sport Select, Ziggo Sport 14, beIN Sports Connect New Zealand, beIN SPORTS 1 New Zealand, SuperSport 3 Nigeria, TV2 Sumo, TV2 Sport Premium, DIRECTV Sports Peru, Canal+ Sport Online, Canal+ 4K Ultra HD, Canal+ Polska, nc+ GO, Sport TV2, DIRECTV Sports Puerto Rico, Telekom Sport 2 Romania, NTV+ Sport Online, Match TV Football 1, Match TV Game, 102 (HD) mio Stadium, mio Stadium 108, SportKlub 1 Slovenia, SuperSport Maximo, #Vamos, Viaplay Sweden, S Sport+, S Sport, Digiturk Play, OLL.tv, Futbol 2, DIRECTV Sports Uruguay, DIRECTV Sports Venezuela, K+PM
You can follow the action with us by downloading the This is Anfield app for free.