The Reds arrived in America earlier this week, and have been training in Indiana in preparation for a three-game jaunt that begins against Klopp’s old club.
Dortmund provide a significant step up in competition after Liverpool’s victories over Tranmere and Bradford, and will serve as a closer comparison to the sides on the fixture list in the Premier League.
Nevertheless, injuries and absences ensure Klopp has maintained a youthful edge to his squad in the States, which is reflected on the teamsheet.
Simon Mignolet keeps his place between the sticks, with youngster Dan Atherton and veteran Andy Lonergan among the subs.
Klopp is then set to rotate his XI again at the break, with the likes of Rhian Brewster among the subs.
Not in the squad are Adam Lallana and Bobby Duncan, with the duo suffering knocks in training. Lallana is said to have a dead leg, while Duncan has a minor foot injury.
Liverpool: Mignolet, Clyne, Matip, Gomez, Larouci, Fabinho, Milner, Oxlade-Chamberlain, Wilson, Origi, Kent
Substitutes: Atherton, Lonergan, Van Dijk, Wijnaldum, Lovren, Henderson, Brewster, Robertson, Lewis, Phillips, Jones, Hoever, Woodburn, Alexander-Arnold.