Klopp initially avoided a touchline ban following his dismissal in the 1-0 victory over Man City on October 16, instead being fined £30,000.
But the FA revealed that they would appeal the decision on November 4, and it has now been confirmed that the German will be banned for Saturday’s clash with Southampton.
The news was announced less than 24 hours before kickoff at Anfield, with the fine upheld and Klopp warned over his future conduct.
It is not the first time Klopp has missed a game while in charge at Liverpool, but it is the first time he has done so due to a suspension.
It means he will next take charge of a competitive game in the Carabao Cup fourth round against Man City in the week commencing December 19.