Nunez has been sidelined since this time last week after suffering a minor hamstring injury, which has seen Cody Gakpo deployed up front in his absence.
The Dutchman has struggled to adjust to a different role, as a natural left winger, while Klopp has been required to shuffle his fringe players for the wide positions alongside Mohamed Salah.
And speaking after the 1-0 victory at Molineux, Klopp revealed his “hope” that Nunez will be available when Chelsea arrive at Anfield for Saturday lunchtime.
“I hope that Darwin is coming back in training tomorrow or Thursday, so might be then in contention, of course,” he explained.
Before the third-round replay, however, the manager admitted that “not all players who played the last game are available now, for different reasons.”
Roberto Firmino and Virgil van Dijk remain sidelined along with Luis Diaz, Diogo Jota and Arthur, and Calvin Ramsay has not been in a matchday squad since the Carabao Cup loss to Man City on December 22.
“I don’t think it would be now right after one game to say ‘OK now that’s the team for the next eight weeks’,” he said.
Klopp did add, though: “But of course, the door is open for everybody. We have to fight, whoever’s ready to fight has a good chance to play.”