Derby are the favourites for the drop and have struggled so far with just one point from the opening four fixtures and also lost to Blackpool in the Carling Cup on penalties this week.
Jamie Carragher is ruled out with the rib injury he suffered at Sunderland last week, and Steven Gerrard is unlikely to be risked. Fabio Aurleio and Harry Kewell are the only other 2 players out with longer term injuries.
Fernando Torres is expected to replace Peter Crouch up front but Dirk Kuyt could keep his place. Xabi Alonso could return in midfield and Steve Finnan is expected back in at right back.