League disappointment needs to be put aside as the Reds travel to Madrid to face nine times Eurpean Cup Winners, Real.
The Spanish giants are hitting form under new boss and former Spurs manager Juande Ramos. They thrashed Real Betis 6-1 at the Bernabeu on Saturday night.
The two sides have only ever met once in Europe before, the 1981 final.
Liverpool will be hoping captain Steven Gerrard is available after injury, he returned to training last week but wasn’t fit in time for the disappointing 1-1 home draw with Man City which leaves Liverpool seven points behind Man United.
Kick off is 7:45pm (UK), live on Sky Sports.