The two teams played out a 1-1 draw last Saturday evening, Simon Church opening for the Royals before Steven Gerrard equalised with a cross which ended up finding the net.
Javier Mascherano will now serve the final match of his four game ban in this fixture rather than the Spurs match. That means Rafa Benitez must choose between keeping Gerrard deeper alongside Lucas Leiva, or bringing Alberto Aquilani back into the side.
Liverpool are without defenders Glen Johnson and Martin Kelly, and midfielders Nabil El Zhar and Albert Riera.
Kick off is 7:45pm (UK).
Still available at the ticket office. Priced £24 (all stands) and £36 for Adult/Child in the Anfield Road End.
The match is live on ITV1 (UK).
Liverpool: Reina, Carragher, Skrtel, Aurelio, Darby, Insua, Benayoun, Gerrard, Lucas, Torres, Ngog, Aquilani, Kuyt, Kyrgiakos, Degen, Babel, Cavalieri, Spearing
Reading: Federici, Ingimarsson, Bertrand, Pearce, Cisse, Gunnarsson, Matejovsky, Kebe, McAnuff, Sigurdsson, Long, Rasiak, Hamer, Mills, Robson-Kanu, Karacan, Howard, Church
Referee: Phil Dowd (Staffordshire)
Assistant referees: Andy Garratt & Bobby Madley
Fourth official: Rob Shoebridge