Liverpool will be eyeing a return to Wembley for the semi-finals of this competition, after being victorious in lifting the Carling Cup last month.
Hat-trick hero of Tuesday night Steven Gerrard starts alongside Stewart Downing and Jay Spearing in midfield, Maxi Rodriguez returning to the starting eleven.
Dirk Kuyt and Jordan Henderson drop to the bench.
Liverpool: Reina; Kelly, Skrtel, Carragher, Enrique; Maxi, Gerrard, Spearing, Downing; Carroll, Suarez.
Subs: Doni, Coates, Kuyt, Adam, Henderson, Flanagan, Shelvey.
Stoke City: Sorensen, Wilkinso, Shawcros, Hut, Wilson, Shotton, Whitehead, Whelan, Etherington, Walters, Crouch.
There may be a 30 second applause before the game for Bolton’s Fabrice Muamba, who is in a critical condition in intensive care after suffering a cardiac arrest during Bolton’s Cup tie with Spurs at White Hart Lane yesterday.
Kick-off at Anfield is 4pm and it’s live on ITV 1.