Craig Bellamy has been preferred to Andy Carroll to partner Luis Suarez up front in what has been billed as make or break for Kenny Dalglish’s Liverpool future.
The Reds also see Martin Skrtel and Daniel Agger start in central defence, with Jamie Carragher on the bench.
Jay Spearing, Jordan Henderson and Steven Gerrard make up the midfield, along with winger Stewart Downing.
Two former Reds players are on the bench for Chelsea this afternoon – Fernando Torres and Raul Meireles.
Liverpool: Reina, Johnson, Skrtel, Agger, Enrique, Spearing, Henderson, Gerrard, Downing, Bellamy, Suarez.
Subs: Doni, Carroll, Maxi, Kuyt, Shelvey, Kelly, Carragher.
Chelsea: Cech, Bosingwa, Ivanovic, Terry, Cole, Lampard, Mikel; Ramires, Mata, Kalou, Drogba.
Subs: Turnbull, Essien, Bertrand, Meireles, Sturridge, Torres, Malouda.
Referee: Phil Dowd
Kick-off at Wembley is 5.15pm and it’s live on ITV1, ITV 1 HD, ESPN and Sky 3D.