Boss Brendan Rodgers has opted to field Jonjo Shelvey in the central striker role usually occupied by Luis Suarez. The midfielder scored two against Young Boys in the return game earlier in the group.
While Joe Cole gets another chance to attempt to impress, he and Oussama Assaidi will support Shelvey in attack.
A midfield three of Jordan Henderson, Nuri Sahin and Suso line-up in front of a back-four featuring Stewart Downing at left back.
Pepe Reina gets the nod in goal ahead of Brad Jones, presumably to work his way back to full match fitness after his recent injury lay-off.
The match is live on ITV4 in the UK.
Liverpool: Reina, Wisdom, Carragher, Skrtel, Downing, Henderson, Sahin, Suso, Assaidi, Cole, Shelvey.
Subs: Jones, Enrique, Coates, Gerrard, Allen, Sterling, Suarez.