Flanagan will be out for several weeks with a hamstring injury, after starting the last six games for Liverpool at left-back.
Cissokho hasn’t played since Liverpool’s 4-0 victory over Fulham at Anfield on November 9th.
Liverpool: Mignolet, Cissokho, Skrtel, Sakho, Johnson, Lucas, Allen, Henderson, Sterling, Coutinho, Suarez.
Substitutes: Jones, Toure, Agger, Alberto, Aspas, Moses, Smith.
Manchester City: Hart, Zabaleta, Lescott, Kompany, Kolarov, Fernandinho, Yaya Toure, Nasri, Silva, Negredo, Navas.
Substitutes: Pantilimon, Clichy, Boyata, Garcia, Milner, Dzeko, Nastasic.
Manchester City vs Liverpool gets underway at 5.30pm and is live on BT Sport 1.