The Croatian international defender lines up against his former club, whilst fellow ex-Saint Rickie Lambert starts on the bench.
Lovren made a goalscoring start to his Reds career last Sunday, scoring Liverpool’s second in a 4-0 pre-season friendly win over Borussia Dortmund.
On-loan full-back Javier Manquillo so makes his full debut for the club.
Lucas is preferred to Emre Can and Joe Allen in midfield.
Liverpool: Mignolet, Manquillo, Johnson, Skrtel, Lovren, Gerrard, Lucas, Henderson, Coutinho, Sterling, Sturridge.
Substitutes: Jones, Toure, Sakho, Allen, Ibe, Can, Lambert.