The Reds were riding high in the league table, with the league title in their hands and only three games left to play. However, things quickly unravelled as Mourinho's tactical masterclass saw the visitors stifle their free-flowing opponents with a disciplined defensive display which centred around getting men behind the ball and hitting on the counter-attack.
Steven Gerrard's slip to allow Demba Ba to race through and break the deadlock just before half-time has been translated into a song which far from being a Chelsea fans' favourite is sung at grounds around the country when the former England captain is in town.
Willian added a late second to spell the beginning of the end of the Merseysiders' title dream and Liverpool are looking for revenge.
What may help them this time around is the expectation Chelsea, as league leaders and with summer signings Diego Costa and Cesc Fabregas in sparkling form, will not come to kill the game.
"It is a very important game when you think what they did to us last season," said Toure, whose defensive performance in the 1-0 defeat to Real Madrid in the Bernabeu has put him in contention to start at the expense of £20million summer signing Dejan Lovren.
"That cost us the league and now we have the chance to beat them. I can't wait for that honestly.
"This season they will attack, with the players they have they can't defend (all the time).
"I think they will just try to score goals and we will try to score goals."
Most of Liverpool's big names are expected to return at the weekend but Rodgers was impressed by the performance of some fringe players in the Bernabeu and suggested those who were benched should not automatically assume they will earn a recall.
Midfielder Joe Allen, who started both matches against Madrid either side of two Premier League starts, insists players accept regular changes are part of modern-day football.
"Sometimes you can't win with a squad rotation policy but it is the only way with the demands we have and the added games we have this season," he said,
"That is definitely going to get us the best results over the course of a full season.
"You can see the quality we have throughout and everyone is competing for a spot, and that is exactly what you need if you want to be successful."
The Wales midfielder also believes their Madrid experience will be beneficial facing Chelsea.
"When you compete against the best teams and you perform the way we did there are elements of it which will certainly help us," he added.
"Parts of that performance will hold us in good stead going into the Chelsea game.
"They have started the season very well but they have to come to Anfield and we know if we bring our 'A' game we can compete against anyone in the league."
Allen said it was important to put April's encounter behind them.
"I think sometimes as a player you feel like you are owed one I guess and it wasn't easy (for us) for them to come and take the three points off us, but we can't focus too much on last season," he said.