Meanwhile, goalkeeper Danny Ward makes his Liverpool debut, having returned from a loan spell with Aberdeen in January, with Klopp shuffling his pack following Thursday night’s exploits in the Europa League.
Only one players keep his place from the Reds 4-3 win at home to Borussia Dortmund, with Roberto Firmino joining Sheyi Ojo and Jordon Ibe in support of Daniel Sturridge, in what looks set to be a 4-2-3-1 setup.
Alongside Stewart in midfield, Joe Allen will take up a key role in linking play in the middle of the park.
Joining Lucas ahead of Ward in defence, Connor Randall, Kolo Toure and Brad Smith make up a new-look back four.
Klopp will no doubt have had Wednesday night’s Merseyside derby in mind when he chose his side to take on Bournemouth at Dean Court, but making 10 changes from the win over Dortmund, it is a considerable risk by the German.
Eddie Howe’s Bournemouth head into this clash buoyed by a 2-1 win away to Aston Villa last weekend, with the Cherries looking to secure a mid-table finish in the league.
Liverpool: Ward; Randall, Lucas, Toure, Smith; Allen, Stewart; Ibe, Firmino, Ojo, Sturridge
Subs: Mignolet, Sakho, Flanagan, Milner, Coutinho, Lallana, Origi
Bournemouth: Boruc; Francis, Elphick, Cook, Daniels; Gosling, Surman; Ritchie, Gradel, Stanislas; King
Subs: Federici, Wiggins, O’Kane, Macdonald, Pugh, Grabban, Wilson