That means a substitute role for Daniel Sturridge.
James Milner continues at left-back.
Ragnar Klavan misses the game due to injury; Lucas Leiva is therefore the backup centre-back on the bench – despite having only just returned to injury and having played 45 minutes for the under-23s at Arsenal last night.
Kick off at White Hart Lane is 12.30pm (UK).
Liverpool: Mignolet, Clyne, Matip, Lovren, Milner, Henderson, Wijnaldum, Lallana, Mane, Coutinho, Firmino.
Subs: Manninger, Grujic, Moreno, Lucas, Sturridge, Origi, Stewart.
Spurs: Vorm, Walker, Alderweireld, Vertonghen, Rose; Dier, Wanyama, Eriksen, Alli, Lamela; Kane.
Subs: McGee, Carter-Vickers, Davies, Onomah, Winks, Janssen, Son