It is not believed to be related to the heel issues Henderson suffered throughout 2016, but remains a concern for Klopp.
Speaking before the game, Klopp said he was hoping the 26-year-old will be back in 10 days’ time.
“We’ll miss Jordan, but hopefully it’s not that serious,” he explained.
“He’s in a lot of pain in the moment, but maybe in 10 days he can be back.
“Today we still have a really good lineup, especially with Emre.”
Matip missed his ninth game of the season through injury on Monday afternoon, with the centre-back struggling with a recurring ankle injury.
It remains to be seen whether Henderson’s injury affects Lucas’ rumoured move to Inter Milan.
The Brazilian was expected to join Inter on loan until the end of the season, with the option to join the Serie A side on a permanent deal in the summer.
However, no deal has been brokered as of yet, and with Liverpool’s longest-serving player likely called upon in the coming weeks, Klopp’s stance over his future could well change.