Hampering by injuries and poor form throughout his squad, however, Klopp’s selection options were limited as he prepared for a key clash.
The German has brought in Ragnar Klavan, in his only change against Arsene Wenger’s north London side.
Can has been in hit-and-miss form for the Reds this season, but restored to his natural role, he will hope to dominate in the middle of the park against the Gunners.
He will be tasked with providing Liverpool with the stability they require to attack in numbers, with Klopp keeping faith in Sadio Mane, Philippe Coutinho and Roberto Firmino as his three-man forward line.
Like Henderson, Daniel Sturridge is sidelined, with the England striker picking up a hip injury while in rehabilitation following illness.
In the 223rd meeting between the two sides in history, Liverpool will be desperate to secure their second win over Arsenal this season.
After a 3-1 humiliation at the hands of Leicester City on Monday night, this is imperative.
Liverpool: Mignolet; Clyne, Matip, Klavan, Milner; Can, Lallana, Wijnaldum; Mane, Coutinho, Firmino
Substitutes: Karius, Lovren, Lucas, Moreno, Alexander-Arnold, Woodburn, Origi
Arsenal: Cech; Bellerin, Mustafi, Koscielny, Monreal; Coquelin, Xhaka; Oxlade-Chamberlain, Iwobi, Welbeck; Giroud
Substitutes: Ospina, Gabriel, Gibbs, Ramsey, Walcott, Alexis, Lucas