Origi had only made six league starts prior to the weekend, but two key injuries have forced Jurgen Klopp to turn to the 21-year-old Belgian.
Klopp has made just one change to the side that won 3-1 against Arsenal last time out, as he seeks back-to-back league victories for the first time in 2017.
Simon Mignolet keeps his place in goal, with Klopp reiterating his faith in his goalkeepers in the buildup to the game.
Burnley are yet to win away from home this season, heaping pressure on Klopp’s side to perform and improve on their 2-0 defeat at Turf Moor back in August.
Origi’s involvement hands the former Lille striker with a big challenge, and he can stabilise his position with a strong performance.
Along with Henderson, Sturridge and Firmino, Dejan Lovren also misses out through injury, with Klopp forced to field a youthful host of substitutes.
Liverpool: Mignolet; Clyne, Matip, Klavan, Milner; Can, Lallana, Wijnaldum; Mane, Coutinho, Origi
Substitutes: Karius, Lucas, Gomez, Moreno, Alexander-Arnold, Wilson, Woodburn
Burnley: Heaton; Lowton, Keane, Mee, Ward; Boyd, Barton, Hendrick, Arfield; Barnes, Gray
Substitutes: Robinson, Tarkowski, Westwood, Brady, Darikwa, Agyei, Vokes