The Senegal international scored his 13th goal of the season to open the scoring, but suffered a serious looking injury early in the second half.
He was eventually replaced by Divock Origi in the 57th minute, having attempted to return to the pitch but then collapse to the ground.
Speaking in his post-match press conference, Jurgen Klopp said he had seen Mane in the changing room but wasn’t sure on the exact nature of the injury.
“It doesn’t look like he’ll be ready for Wednesday,” said Klopp, referring to the Reds’ home game against Bournemouth.
“Hopefully it’s not too serious. We will see.”
Asked what the injury is, Klopp said: “I don’t know exactly, and I don’t want to speculate. Doesn’t look like it’s just a knock. It didn’t look like he felt comfortable.”
On a more positive note, reporter Carl Markham reported that Mane walked out of Anfield showing that it may not be as bad as first feared – and most positively, he did not have a brace on.
Sadio Mane walking through mixed zone unemcumbered. Obviously there are underlying issues with his knee but doesn't look as bad as feared
— Carl Markham (@carlmarkham) April 1, 2017
Liverpool struggled in Mane’s absence when he was at the AFCON in January and will now be hoping he isn’t sidelined for the rest of the season.