The Reds last featured in Europe’s top-tier tournament in 2014 under Brendan Rodgers, taking five points from six group games, including back-to-back losses to Real Madrid.
After a fourth-placed finish in the Premier League last time out, and a comprehensive victory over Hoffenheim in August’s play-off qualifier, Klopp’s side are in strong European form.
The Senegal winger is not suspended for the Champions League, however, and is among Klopp’s side as they make their continental comeback.
Alongside Mignolet on the substitutes’ bench, Ragnar Klavan, Andrew Robertson, James Milner, Alex Oxlade-Chamberlain, Philippe Coutinho and Daniel Sturridge provide Klopp with a strong reserve selection.
Liverpool: Karius; Gomez, Matip, Lovren, Moreno; Henderson, Can, Wijnaldum; Mane, Salah, Firmino
Substitutes: Mignolet, Klavan, Robertson, Milner, Oxlade-Chamberlain, Coutinho, Sturridge
Sevilla: Rico; Mercado, Kjaer, Pareja, Escudero; N’Zonzi, Pizarro, Banega; Navas, Correa, Ben Yedder
Substitutes: Soria, Corchia, Carrico, Krohn-Dehli, Sarabia, Muriel, Vazquez