Oxlade-Chamberlain made the £35 million switch from Arsenal on deadline day, becoming the fourth new arrival on Merseyside this summer.
But having moved amid speculation over his position at Anfield, it was unclear how Klopp planned to use Oxlade-Chamberlain.
“[He can play] a few positions. He’s a very good football player, good in small spaces, good in big spaces,” he said.
“You want to have him on the pitch as often as possible, and he fits really well in different lineups.
“In the system we play in this moment he can play four positions, both No. 8s and both wingers.”
Whether he features against City remains to be seen, though, with Klopp admitting Liverpool’s new No. 21 will need time to “adapt.”
“It doesn’t make too much sense to say ‘come on’, if you don’t have to, give him the time,” he added.
“If he had been in since the start of July, it probably would have been much better.”
The midfielder will likely take up a place on Klopp’s substitutes’ bench, boosting the 50-year-old’s options for a crucial clash significantly.