The Reds trained at Melwood on Monday morning ahead of their flight out to Moscow later in the day, with Klopp set to hold his pre-match press conference at 5pm (BST).
Having produced an improved performance in Saturday evening’s 3-2 win away to Leicester City, Klopp’s side will be looking to build on their form.
Ben Woodburn was missing, however, with the 17-year-old likely to be part of Steven Gerrard’s U19s squad for the UEFA Youth League once again.
The young Reds will take on their Spartak counterparts at 12pm (BST) on Tuesday, looking for a similar display to last time out.
Captaining Gerrard’s side at Prenton Park against Sevilla, Woodburn was central to an excellent 4-0 victory.
Spartak find themselves in miserable form heading in their second Group E outing, having won just twice in 11 games in the Russian Premier League this season, currently sitting eighth.
They were also held to a 1-1 draw away to Maribor in the Champions League earlier in September.
Speaking to This is Anfield ahead of the clash, Russian football expert and LFCTV commentator John Bradley cast a doubtful view over Spartak’s chances.
“Once Liverpool’s players have seen the very rowdy atmosphere at kickoff and the outstanding tifos behind the goal, I fully expect them to dominate Spartak and run out comfortable winners,” he said.
Liverpool Squad vs. Spartak Moscow
Goalkeepers: Mignolet, Karius, Ward
Defenders: Matip, Lovren, Klavan, Moreno, Robertson, Alexander-Arnold, Flanagan
Midfielders: Henderson, Can, Wijnaldum, Oxlade-Chamberlain, Milner
Forwards: Mane, Salah, Coutinho, Firmino, Sturridge, Solanke
In training but not in squad to Moscow: Markovic, Ings, Grujic