The Reds return to Premier League action with a showcase clash against the defending champions, looking to extend their winning run in the English top flight to four games.
Amid a winter schedule that sees them play 13 games over just 45 days, Klopp is required to rotate his selection between games.
And Saturday is no different, with the German making five changes in search of three points against the Blues.
Adam Lallana makes his first appearance in the matchday squad since the end of last season.
Liverpool have not lost in their last five meetings with Chelsea, and victory on Saturday will see them go level on points with Antonio Conte’s side.
Liverpool: Mignolet; Gomez, Matip, Klavan, Moreno; Henderson, Milner, Coutinho; Salah, Oxlade-Chamberlain, Sturridge
Substitutes: Karius, Alexander-Arnold, Robertson, Wijnaldum, Lallana, Mane, Firmino
Chelsea: Courtois; Azpilicueta, Christensen, Cahill; Zappacosta, Drinkwater, Kante, Bakayoko, Alonso; Hazard, Morata
Substitutes: Caballero, David Luiz, Rudiger, Moses, Fabregas, Willian, Pedro