The Reds have made the 60-mile trip to the Britannia Stadium as they bid to extend their unbeaten run to seven games and build on their recent form.
Meanwhile, Stoke have won just twice in their last 10 games in all competitions, and have lost to Liverpool in each of their last four meetings.
With a trip to East Sussex to come on Saturday, when the Reds take on Brighton, Klopp has rotated his side once again, making six changes.
Simon Mignolet continues in goal, with the Belgian not at fault for Willian’s late equaliser in midweek, beaten by a fortunate cross-shot.
Stoke City: Grant; Zouma, Shawcross, Martins-Indi; Diouf, Fletcher, Allen, Pieters; Shaqiri, Choupo-Moting, Crouch
Substitutes: Haugaard, Wimmer, Adam, Afellay, Ramadan, Jese, Berahino
Liverpool: Mignolet; Gomez, Matip, Lovren, Moreno; Can, Wijnaldum, Oxlade-Chamberlain; Mane, Firmino, Solanke
Substitutes: Karius, Alexander-Arnold, Milner, Henderson, Coutinho, Salah, Sturridge