The Reds will qualify for the knockout stages with a draw, and will clinch first place with a win, or a draw if Sevilla fail to win.
If they lose they are out unless Sevilla are also defeated (as Liverpool would be below Spartak in a two-way head-to-head or would be third in a three-way head-to-head on nine points).
In Matchday 2 the sides drew 1-1. The hosts took the lead through Fernando on 23 minutes with Philippe Coutinho equalising eight minutes later.
A Reassuring Record
The Reds are unbeaten in the last 13 European group games, winning four with nine draws.
Liverpool are unbeaten in the last 12 home games in Europe—winning eight and drawing four—since losing 3-0 to Real Madrid in October 2014.
That is their only Anfield defeat in the last 17 European fixtures.
The Reds have not lost any of their last four final group games of a European campaign. However, they have won only one of their last five matches on Matchday 6.
Mo Salah has scored 11 times in his last 10 games for the Reds in all competitions.
Since the goalless draw with Manchester United in October, Liverpool have scored 33 times in 10 games.
They have scored three or more goals in all but one of the last eight games (their last home game against Chelsea).
Spartak, like Liverpool, currently lie fourth in their league, eight points behind city rivals Lokomotiv.
They won 1-0 last time out away at Arsenal Tula—Denis Glushakov netting the only goal in the 90th minute.
The Russians have lost one of their last 19 games in all competitions—last month’s 2-1 defeat at Sevilla—after losing three of their opening eight fixtures of the campaign.
Since that defeat in Spain they have won four and drawn one of the last five.
Spartak have kept one clean sheet in the last eight league and cup games.
Luiz Adriano has scored four goals in his club’s last five games.
This Season’s Scorers
Liverpool: Salah (17), Firmino (11), Coutinho (6), Mane (5), Can (4), Sturridge (3), Alexander-Arnold (2), Oxlade-Chamberlain (2), Henderson (1), Matip (1), Wijnaldum (1), own goals (2)
Spartak Moscow: Promes (13), Luiz Adriano (9), Glushakov (5), Melgarejo (5), Fernando (4), Pasalic (4), Ze Luis (4), Samedov (3), Dzhikiya (1), Kutepov (1), Pedro Rocha (1), own goals (1)
* Stats courtesy of LFC statistician Ged Rea.