Both Salah and Mane were named among the final three for the award, handed out by CAF, along with Pierre-Emerick Aubameyang.
Salah came out on top after a stellar half-season with Liverpool, following on from a productive second half of the campaign last term with AS Roma.
In addition, Salah produced a vital contribution in Egypt’s World Cup qualifying campaign, guiding them to the finals in Russia with a succession of goalscoring performances.
Mane was one of the Reds’ most important players last season and, while not quite hitting those heights so far in 17/18, has still found the back of the net eight times.
The Senegalese attacker has been named in the CAF Team of the Year for the past two years and his top-two finish solidifies his place as one of the Continent’s best.
Salah, for his part, was also in the 2016 Team of the Year, was named in the AFCON Team of the Tournament in 2017 and won the BBC African Player of the Year award last month.
Being named now as the very best player in Africa, replacing last year’s winner Riyad Mahrez, caps off a stunning year for the Reds’ No. 11.