Still fighting for a top-four finish in the league, Liverpool can maintain the gap between them and fifth-placed Chelsea with another three points at home.
They take on a Bournemouth side who have won just once in their last six games, and still unbeaten at Anfield in the league they can head into the 5.30pm kickoff with confidence.
Despite his players’ European exertions, Klopp has largely kept the same side from the Etihad, with just one alteration.
Loris Karius remains in goal, with the manager going all in on his new No. 1, who has so far kept 13 clean sheets and conceded just 19 goals in 25 games this season.
Jordan Henderson returns in midfield after sitting out the victory over City due to suspension.
Liverpool: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Wijnaldum; Oxlade-Chamberlain; Salah, Mane, Firmino
Substitutes: Mignolet, Klavan, Moreno, Milner, Woodburn, Solanke, Ings
Bournemouth: Begovic; Francis, S. Cook, Ake, Daniels; Fraser, L. Cook, Gosling, Ibe; King; Defoe
Substitutes: Boruc, Simpson, Smith, Surman, Pugh, Mousset, Wilson