The Reds take on their city rivals having thrashed Man City at Anfield three days previous, but with a return trip to the Etihad to come on Tuesday their focus is split.
While victory over Everton at Goodison Park will be a major boost both in terms of the top-four race and, fundamentally, morale, rotation during a busy period is vital.
As a result, and factoring in the absences of six first-team players, Klopp has named an altered selection to that which thrived in the Champions League.
This marks Ings’ first start under the manager, and he will be looking to score his first senior goal since he struck in the 1-1 draw with Everton at the same ground back in 2015.
Everton: Pickford; Coleman, Jagielka, Keane, Baines; Schneiderlin, Davies, Rooney; Walcott, Bolasie, Tosun
Substitutes: Joel, Funes Mori, Martina, Baningime, Gueye, Calvert-Lewin, Niasse
Liverpool: Karius; Lovren, Van Dijk, Klavan; Clyne, Henderson, Wijnaldum, Milner; Mane, Ings, Solanke
Substitutes: Mignolet, Masterson, Alexander-Arnold, Oxlade-Chamberlain, Jones, Camacho, Firmino