But with a packed Anfield behind them, Jurgen Klopp‘s side will be desperate to secure a positive result against City ahead of next week’s trip to Manchester.
Restricted by absences, Klopp has made just two alterations to the side that won 2-1 at Crystal Palace on Saturday, including an interesting, non-enforced change.
In midfield, captain Jordan Henderson is in danger of suspension for the second leg if he picks up another yellow card, but is required due to Can’s back injury.
With his hands tied, Klopp drafted five academy youngsters into his squad for training on Tuesday afternoon.
U23s centre-back Conor Masterson makes the substitutes’ bench, for his second appearance in the Liverpool matchday squad and his first since being unused in the 2-2 draw with Exeter City in the FA Cup third round in 2015/16.
Liverpool: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Henderson, Milner, Oxlade-Chamberlain; Salah, Mane, Firmino
Substitutes: Mignolet, Masterson, Clyne, Moreno, Wijnaldum, Solanke, Ings
Man City: Ederson; Walker, Kompany, Otamendi, Laporte; Fernandinho, Gundogan, D Silva; Sane, De Bruyne, Jesus
Substitutes: Bravo, Stones, Danilo, Delph, Zinchenko, Bernardo, Sterling