Salah picked up the injury after a cynical challenge from Real Madrid centre-back Sergio Ramos, and after attempting to continue was forced off the field on 30 minutes.
Liverpool went on to lose in Kyiv, as Karim Benzema’s opener and Gareth Bale’s brace sealed Real’s third successive European Cup win.
The Reds can take heart from their spirited display, exemplified by Sadio Mane‘s equaliser on 55 minutes, but now return to Merseyside without a trophy.
Without doubt, Salah’s departure was a major moment in the game and was the focus of Jurgen Klopp‘s post-match press conference.
“Of course, it (Salah injury) was a big moment in the game,” said Klopp.
“It was a kinda harsh challenge, it’s like wrestling. It’s unlucky that Mo fell on his shoulder. It’s a really serious injury.
“All the medical department, what they said so far, it doesn’t look good.”
The Liverpool manager explained that the Reds’ 44-goal forward is in hospital for an X-ray, explaining: “It’s the shoulder or the collarbone itself. It doesn’t look good.”
A dislocated shoulder can take three to four months to fully recover from, perhaps even ruling Salah out of the start of next season.
The Reds’ No.11 fired Egypt to their first World Cup in 28 years when his late penalty sealed a 2-1 win over Congo in October, but now the Pharoahs are likely to head to the tournament without their talisman.