The Blues surrendered their 100 percent record in the league as they were held to a 0-0 draw by West Ham on Sunday, meaning the Reds are now the only side with a perfect streak.
Before Saturday’s mouthwatering title clash at Stamford Bridge, however, Chelsea travel to Anfield for a third-round cup tie in midweek.
Both managers are expected to make changes for the meeting, with the priority already the league and Europe, but Sarri’s selection could be enforced.
Antonio Rudiger came off with an injury midway through the second half at the London Stadium, replaced by Gary Cahill, who made his first appearance of the season.
Speaking after the game, Sarri told reporters he hoped Rudiger’s issue was “nothing serious,” but added that he was expecting a layoff of “maybe three or four days, no more.”
This would rule the previously ever-present centre-back out for Wednesday, while Pedro (shoulder) will also miss out, and is a doubt for the league clash too.
“In this moment of the season, Pedro is a very important player,” Sarri explained.
“We are trying to have him at the end of the week, but I don’t know at the moment.”
Sarri has already asserted that youngsters such as Ruben Loftus-Cheek, Ethan Ampadu and Callum Hudson-Odoi aren’t ready for first-team involvement, which leaves him short for Wednesday.
He fielded a struggling back four of Rudiger, David Luiz, Cesar Azpilicueta and Marcos Alonso against West Ham, and now faces the prospect of a centre-backing pairing of Luiz and Cahill.
While he certainly has options in midfield following the return of Cesc Fabregas, it remains to be seen how they configure.
And in attack, neither Olivier Giroud or Alvaro Morata are firing so far this season, and with Eden Hazard playing 90 minutes at the weekend it’s questionable whether he will start at Anfield.
“Must win, in football, doesn’t exist. We have to play against a very, very good team,” he said.