Here, Press Association Sport looks at the talking points ahead of the action.
Can Tottenham Cope Without Harry Kane?
England captain Kane has been ruled out until March with an ankle injury leaving Spurs with a striker crisis.
Son-Heung Min is also away at the Asian Cup while Vincent Janssen is frozen out and Fernando Llorente has started just one league game in 17 months.
Lucas Moura seems the only alternative up front but he has been battling a knee problem. Spurs have been reliant on Kane and must now cope or buy a replacement.
What Does the Future Hold for Huddersfield?
Rooted to the bottom of the Premier League Huddersfield are now managerless after David Wagner’s departure.
The Terriers host Manchester City on Sunday seven points from the safety line, with a managerial search now taking priority over January reinforcements for their survival effort.
Sporting director Olaf Rebbe has also departed as the club look for a fresh start but that increasingly looks like being in the Sky Bet Championship.
Can Arsenal Keep Their Champions League Hopes Alive?
But without serious strengthening cracking the top four again remains a tall order for a Gunners side who lost 1-0 at West Ham last week.
Marco Silva Needs to Stop Flattering to Deceive
They are 11 points off sixth-placed Manchester United and a mid-table finish, without European football next season, looks increasingly likely.
Will Liverpool Slip up Against Crystal Palace Again?
The leaders host the Eagles, with Palace having won three of their last four trips to Anfield.
Their 2-1 win in April 2017 is Liverpool’s last home league defeat, with the Reds now unbeaten in 31 top-flight games at Anfield.