The Reds have not enjoyed success in this competition in recent years, with Jurgen Klopp‘s priorities shifting over his reign as manager.
After reaching the final in 2015/16 and the semi-finals in 2016/17, Klopp saw his side exit at the third-round stage in both of the past two seasons, losing to Leicester and Chelsea.
Tonight brings a different challenge, with League One outfit MK Dons welcoming Liverpool to Buckinghamshire, and the champions of Europe are heavy favourites, rotation or not.
Klopp is likely to hand a number of players their senior debut, while others are expected to receive much-needed game time after a consistent start to the campaign for the first team.
Can the Reds reach the fourth round despite shuffling their pack at Stadium MK?
Check This Is Anfield for the latest team news ahead of the match.
You can also follow the game by downloading the This is Anfield app, including lineups, live commentary and all the reaction and analysis.
The match gets underway at 7.45pm (BST)—or 2.45pm in New York, 11.45am in Los Angeles, 4.45am (Thursday) in Sydney, 10.45pm in Dubai and 9.45pm in Nairobi.
Check our Rest of the World TV guide below for a list of TV broadcasters showing the match live.
Rest of the World
Supporters can find the Reds’ League Cup third-round clash on the following channels worldwide:
beIN SPORTS CONNECT, beIN Sports HD 2, SuperSport Maximo, SuperSport 3 Africa, ESPN Play Sur, Kayo Sports, DAZN, Klik SPORT, ESPN no Brasil, Watch ESPN Brasil, Play Diema Xtra, Diema Sport 2, Sky Sport 7 beIN Sports, Sky HD, Arena Sport 5 Croatia, Cytavision on the Go, Cytavision Sports 3, TV3 Sport, Viaplay Denmark, Viaplay Finland, Nova Sports 5, Digi Sport 2, Stod 2 Sport, Mola TV, Sky Sports Football (ROI), SPOTV2, TDM HD, Arena Sport 5 Serbia, MaxTV Go, Blue To Go Video Everywhere, Arena Sport 5 Serbia, beIN Sports Connect New Zealand, Viasport 1, Viaplay Norway, Eleven Sports 4 Poland, Sport TV5, Sport TV LIVE, Match TV Football 3, STV 2, DAZN Spain, EuroSport Nordic, Eurosport Player Sweden, Viaplay Sweden, ESPN+
You can follow all the action tonight and throughout 2019/20 with us by downloading the This is Anfield app for iPhone and Android for free.