The Reds are looking for a response to their 2-0 loss at Napoli last time out in Europe, and take on a side back in the continental top tier for the first time since 1994.
Salzburg thrashed Genk 6-2 in their Group E opener, and are currently topping the Austrian Bundesliga with eight wins and a draw from their first nine games, including a 4-1 victory at home to Austrian Wien on Saturday.
Liverpool won their last outing, too, theirs being a hard-fought 1-0 at Sheffield United, with the early kickoff providing ample recovery time for Klopp’s side.
This has allowed the manager to retain much of his starting side from that lunchtime at Bramall Lane, including Adrian, who keeps his place in goal as the medical staff remain cautious over Alisson‘s comeback.
Salzburg’s 17-goal striker Erling Braut Haaland has not been passed fit to start, instead beginning the game on the bench after illness.
Substitutes: Kelleher, Lovren, Milner, Lallana, Keita, Oxlade-Chamberlain, Origi
Salzburg: Stankovic; Kristensen, Onguene, Wober, Ulmer; Minamino, Mwepu, Junuzovic, Szoboszlai; Daka, Hwang
Substitutes: Carlos, Ashimeru, Farkas, Okugawa, Andre Ramalho, Koita, Haaland