This trend is set to continue as, despite Salah’s return from injury, further withdrawals will restrict the manager’s selection in Belgium.
It comes in a relatively low-key but crucial European clash for Liverpool, who after two games sit third in their group with three points, level with Salzburg and one below Napoli.
Victory would present a strong case for progress to the last 16 at the midway point, and this will be the goal after a difficult afternoon in Manchester.
Here’s how Liverpool could line up at the Luminus Arena.
The sight of Salah back in training on Tuesday afternoon was a welcome one, particularly given Divock Origi‘s struggle in his stead at Old Trafford.
They join Xherdan Shaqiri on the treatment table, with the winger heading back to Switzerland for treatment on a calf problem.
Liverpool Squad in Genk
Defenders: Van Dijk, Gomez, Lovren, Robertson
Midfielders: Fabinho, Wijnaldum, Henderson, Keita, Milner, Oxlade-Chamberlain, Lallana
Forwards: Salah, Mane, Firmino, Origi, Brewster
Liverpool’s Starting XI vs. Genk
Without both Matip and Alexander-Arnold, Klopp will be forced into a defensive shakeup, with his right-hand side in need of reinforcement.
Lovren defied pre-match expectations with a strong performance in only his second start of the season so far against Leicester, and could be trusted to partner Virgil van Dijk, with Gomez at right-back.
James Milner is another option to come in at right-back, however, and if Klopp prefers the experience and attacking output of the 33-year-old this could see Gomez start at centre-back instead.
Meanwhile, with Keita receiving praise for “not always doing the obvious things” in his 10-minute showing at United, the manager could be tempted to start the Guinean.
If so, the most attractive prospect would be a trio of Fabinho, Wijnaldum and Keita, which should provide a balance of defence and attack away from home.
And with Salah having been a doubt for Genk as recent as Sunday, Klopp could also opt to name the Egyptian on the substitutes’ bench.
Given Origi’s abject display on the wing against United, Oxlade-Chamberlain would serve as a more progressive option in the front three, and allow Mane to return to the left:
Changes are guaranteed in Belgium, it is just a case of how many, and there are a number of interesting possibilities for Liverpool on Wednesday night.
The introduction of Gomez and Lovren in defence, and the return of Salah, seems the most likely, but with Tottenham to come on Sunday at Anfield, a rejig would ensure fresh legs in both games.