The Reds’ busy December has begun and does so with a Merseyside derby, with the visit of Everton the first of 10 games across four competitions, three countries and two continents in the next month.
Marco Silva’s side are in disrepair, with the manager under growing pressure and defeat potentially seeing them drop into the relegation zone, having won just four of their 14 games so far in the Premier League.
And the events of the weekend will impact on Klopp’s selection for the derby, most notably in goal but likely elsewhere too.
Here’s how Liverpool could take to the field on Wednesday night.
The most notable absence for this game is, of course, Alisson, who is suspended after his red card on Saturday.
Elsewhere, Klopp has confirmed Joel Matip “needs a bit more time” as he recovers from a knee injury that is proving more long-term than originally expected.
Matip and Fabinho will both likely miss the remainder of 2019, which limits Klopp’s options in defence and midfield, but also gives opportunity to others during a period of rotation.
Klopp made three changes to his side for the win over Brighton, and could opt for a similar reshuffle at Anfield in midweek.
While the derby is a must-win, and Klopp has emphasised that Everton cannot be underestimated, this could be a tie that allows rotation.
Perhaps it will be a night for Gomez to return to centre-back, while Keita could be given a chance in midfield and Lallana may even be considered as a stand-in No. 6.
Liverpool’s Starting XI vs. Everton
Providing Adrian with a solid core at the back would be beneficial, with his immediate concession of a free-kick against Brighton certainly questionable in terms of Martin Atkinson’s influence, but still a sign that he requires support.
Adrian; Trent, Lovren, Van Dijk, Robertson; Henderson, Wijnaldum, Keita; Salah, Mane, Firmino
Gomez’s poor outing at right-back in the 1-1 draw with Napoli last time out in the Champions League should serve as evidence enough that the 22-year-old is now defined as a centre-back.
While the south coast could be a better background for his return to his natural role alongside Van Dijk, it could well come against Everton—having excelled in the same fixture this time last year.
He could provide a straight swap for Lovren at the back, while Milner could come in for Wijnaldum in midfield, with Klopp starting his vice-captain in six out of eight Merseyside derbies so far.
Milner and Henderson could line up alongside Oxlade-Chamberlain in an all-English midfield, leaving the likes of Lallana, Keita and Shaqiri as impact substitutes.
So too would be Origi, which could set him up to reprise his heroic role from last season as Salah, Mane and Firmino start again:
Adrian; Trent, Gomez, Van Dijk, Robertson; Henderson, Oxlade-Chamberlain, Milner; Salah, Mane, Firmino
It is difficult to predict how Liverpool will take to the field throughout a congested winter, but Klopp is unlikely to make wholesale changes for any game.
Instead, careful rotation will be implemented, and the Reds should be expected to shape up similarly to Saturday’s victory over Brighton as they seek a 14th league win.